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KMID : 0363619960170020277
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Journal of Korean Oriental Medicine
1996 Volume.17 No. 2 p.277 ~ p.290
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Studies on the effect of Kamikuibitang on the Gastric Ulcer in Rats
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Abstract
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This study was aimed to evaluate the anti-pain effect of Kamikuibitang in acetic acid method and the anti-ulceration effect of Kamikuibitang in indomethacin, aspirin and immobilization stress method in rats.
The rcsults were follows ;
1. The anti-pain effects of Kuibitang and Kamikuibitang were decreased compared with those of control group.
2. In indomethacin and aspirin method, the anti-ulcerative effects of experimental groups were shown compared with those of control group.
3. In immobilization stress method, the anti-ulcerative effect of experimental groups was significantly shown compared with that of control group.
4. The serum gastrin levels of Kuibitang groups showed very significant decrease in indomc thacin-induced and immobilization stress-induced ulcers. The serum gastrin levels of Kamikuibitang groups showed very significant decrease in indomc: thacin-induced, aspirin- induced and immobilization stress-induced ulcers.
5. The serum V_(B12) levels of Kuibitang groups showed very significant increase in both indomc thacin-induced and immobil-ization stress-induced ulcers.
The serum V_(B12) levels of Kamikuibitang groups showed significant increase in aspirin-induced and immobilization stress-induced ulcers whereas very significant increase in indomethacin-induced ulcer.
Acconding to the above results, it was concl anti-ulceration effect as well as anti-pain effect onuded that Kamikuibitang had very significant gastric ulcer in rats.
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